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!
! This file is automatically generated with 
! the System Biology Format Converter (http://sbfc.sourceforge.net/)
! from an SBML file.
!

!
! Model name = Fisher2006_NFAT_Activation
!
! is urn:miriam:biomodels.db:BIOMD0000000123
! is urn:miriam:biomodels.db:MODEL2977131407
! isDescribedBy urn:miriam:pubmed:17031595
!

Model 
 Parameters 
	cytosol=2.69E-13! Compartment: id = cytosol, name = cytosol, constant
	nucleus=1.13E-13! Compartment: id = nucleus, name = nucleus, constant
	k1=2.56E-5	! Parameter:   id =  k1, name = k1, constant
	k2=0.00256	! Parameter:   id =  k2, name = k2, constant
	k16=6.63	! Parameter:   id =  k16, name = k16, constant
	k15=0.00168	! Parameter:   id =  k15, name = k15, constant
	k18=9.6E-4	! Parameter:   id =  k18, name = k18, constant
	k17=0.0015	! Parameter:   id =  k17, name = k17, constant
	k6=9.2E-4	! Parameter:   id =  k6, name = k6, constant
	k5=0.0019	! Parameter:   id =  k5, name = k5, constant
	k14=0.00256	! Parameter:   id =  k14, name = k14, constant
	k13=0.5	! Parameter:   id =  k13, name = k13, constant
	k12=0.00168	! Parameter:   id =  k12, name = k12, constant
	k11=6.63	! Parameter:   id =  k11, name = k11, constant
	k10=0.005	! Parameter:   id =  k10, name = k10, constant
	k9=0.5	! Parameter:   id =  k9, name = k9, constant
	k3=0.005	! Parameter:   id =  k3, name = k3, constant
	k4=0.5	! Parameter:   id =  k4, name = k4, constant
	k7=0.005	! Parameter:   id =  k7, name = k7, constant
	k8=0.5	! Parameter:   id =  k8, name = k8, constant
	k19=1.0	! Parameter:   id =  k19, name = k19, constant
	k20=1.0	! Parameter:   id =  k20, name = k20, constant
	k21=0.21	! Parameter:   id =  k21, name = k21, constant
	k22=0.5	! Parameter:   id =  k22, name = k22, constant
 End Parameters

Variables
	t=0
	Ca_Nuc=1.0	!init 	! Species:   id = Ca_Nuc, name = Calcium in Nucleus; Compartment:nucleus, affected by kineticLaw
	Ca_Cyt=1.0	!init 	! Species:   id = Ca_Cyt, name = Calcium in Cytosol; Compartment:cytosol, affected by kineticLaw
	NFAT_Nuc=5.219E-4	!init 	! Species:   id = NFAT_Nuc, name = NFAT_Nuc; Compartment:nucleus, affected by kineticLaw
	Act_C_Nuc=5.05E-5	!init 	! Species:   id = Act_C_Nuc, name = Active Calcineurin in nucleus; Compartment:nucleus, affected by kineticLaw
	NFAT_Pi_Nuc=2.272E-4	!init 	! Species:   id = NFAT_Pi_Nuc, name = Phosphorylated NFAT in nucleus; Compartment:nucleus, affected by kineticLaw
	NFAT_Act_C_Nuc=9.477E-4	!init 	! Species:   id = NFAT_Act_C_Nuc, name = NFAT Calcineurin complex in nucleus; Compartment:nucleus, affected by kineticLaw
	NFAT_Pi_Act_C_Nuc=2.5E-6	!init 	! Species:   id = NFAT_Pi_Act_C_Nuc, name = Phosphorylated NFAT Calcineurin complex in nucleus; Compartment:nucleus, affected by kineticLaw
	Inact_C_Nuc=0.049198	!init 	! Species:   id = Inact_C_Nuc, name = Inactive Calcineurin in nucleus; Compartment:nucleus, affected by kineticLaw
	NFAT_Cyt=1.101E-4	!init 	! Species:   id = NFAT_Cyt, name = NFAT_Cyt; Compartment:cytosol, affected by kineticLaw
	Act_C_Cyt=9.1E-6	!init 	! Species:   id = Act_C_Cyt, name = Active Calcineurin in cytosol; Compartment:cytosol, affected by kineticLaw
	NFAT_Pi_Cyt=0.0094397	!init 	! Species:   id = NFAT_Pi_Cyt, name = Phosphorylated NFAT in cytosol; Compartment:cytosol, affected by kineticLaw
	NFAT_Act_C_Cyt=6.1E-6	!init 	! Species:   id = NFAT_Act_C_Cyt, name = NFAT Calcineurin complex in cytosol; Compartment:cytosol, affected by kineticLaw
	NFAT_Pi_Act_C_Cyt=2.2E-6	!init 	! Species:   id = NFAT_Pi_Act_C_Cyt, name = Phosphorylated NFAT Calcineurin complex in cytosol; Compartment:cytosol, affected by kineticLaw
	Inact_C_Cyt=0.0097108	!init 	! Species:   id = Inact_C_Cyt, name = Inactive Calcineurin in cytosol; Compartment:cytosol, affected by kineticLaw
 End Variables

Intermediates

R1=nucleus*(k1*NFAT_Pi_Nuc-k2*NFAT_Nuc)	! Reaction: id = R1	! name = Calcineurin dpdnt NFAT dephosphorylation
	R2=nucleus*(k16*NFAT_Nuc*Act_C_Nuc-k15*NFAT_Act_C_Nuc)	! Reaction: id = R2	! name = NFAT Calcineurin complex formation
	R3=nucleus*k18*NFAT_Nuc-cytosol*k17*NFAT_Cyt	! Reaction: id = R3	! name = NFAT transport
	R4=nucleus*k6*Act_C_Nuc-cytosol*k5*Act_C_Cyt	! Reaction: id = R4	! name = Active Calcineurin transport
	R5=nucleus*(k14*NFAT_Act_C_Nuc-k13*NFAT_Pi_Act_C_Nuc)	! Reaction: id = R5	! name = NFAT Calcineurin complex phosphorylation
	R6=nucleus*(k12*NFAT_Pi_Act_C_Nuc-k11*NFAT_Pi_Nuc*Act_C_Nuc)	! Reaction: id = R6	! name = Phosphorylated NFAT Calcineurin complex disassembly
	R7=nucleus*k10*NFAT_Act_C_Nuc-cytosol*k9*NFAT_Act_C_Cyt	! Reaction: id = R7	! name = NFAT Calcineurin complex transport
	R8=cytosol*(k14*NFAT_Act_C_Cyt-k13*NFAT_Pi_Act_C_Cyt)	! Reaction: id = R8	! name = NFAT Calcineurin complex phosphorylation
	R9=cytosol*(k12*NFAT_Pi_Act_C_Cyt-k11*NFAT_Pi_Cyt*Act_C_Cyt)	! Reaction: id = R9	! name = Phosphorylated NFAT Calcineurin complex disassembly
	R10=cytosol*k3*NFAT_Pi_Cyt-nucleus*k4*NFAT_Pi_Nuc	! Reaction: id = R10	! name = Phosphorylated NFAT transport
	R11=cytosol*(k15*NFAT_Act_C_Cyt-k16*NFAT_Cyt*Act_C_Cyt)	! Reaction: id = R11	! name = NFAT Calcineurin complex disassembly
	R17=cytosol*k7*NFAT_Pi_Act_C_Cyt-nucleus*k8*NFAT_Pi_Act_C_Nuc	! Reaction: id = R17	! name = Phosphorylated NFAT Calcineurin complex transport
	R12=cytosol*(k1*NFAT_Pi_Cyt-k2*NFAT_Cyt)	! Reaction: id = R12	! name = Calcineurin dpdnt NFAT dephosphorylation
	R13=cytosol*(k19*Inact_C_Cyt*Ca_Cyt^(3)-k20*Act_C_Cyt)	! Reaction: id = R13	! name = Calcineurin activation
	R14=nucleus*(k19*Inact_C_Nuc*Ca_Nuc^(3)-k20*Act_C_Nuc)	! Reaction: id = R14	! name = Calcineurin activation
	R15=cytosol*k5*Inact_C_Cyt-nucleus*k6*Inact_C_Nuc	! Reaction: id = R15	! name = Inactive Calcineurin transport
	R16=cytosol*k21*Ca_Cyt-nucleus*k22*Ca_Nuc	! Reaction: id = R16	! name = Calcium transport
 End Intermediates

Equations
	$t=1
	$Ca_Nuc=(1/(nucleus))*((-3.0 * R14) + ( 1.0 * R16))
	$Ca_Cyt=(1/(cytosol))*((-3.0 * R13) + (-1.0 * R16))
	$NFAT_Nuc=(1/(nucleus))*(( 1.0 * R1) + (-1.0 * R2) + (-1.0 * R3))
	$Act_C_Nuc=(1/(nucleus))*((-1.0 * R1) + ( 1.0 * R1) + (-1.0 * R2) + (-1.0 * R4) + ( 1.0 * R6) + ( 1.0 * R14))
	$NFAT_Pi_Nuc=(1/(nucleus))*((-1.0 * R1) + ( 1.0 * R6) + ( 1.0 * R10))
	$NFAT_Act_C_Nuc=(1/(nucleus))*(( 1.0 * R2) + (-1.0 * R5) + (-1.0 * R7))
	$NFAT_Pi_Act_C_Nuc=(1/(nucleus))*(( 1.0 * R5) + (-1.0 * R6) + ( 1.0 * R17))
	$Inact_C_Nuc=(1/(nucleus))*((-1.0 * R14) + ( 1.0 * R15))
	$NFAT_Cyt=(1/(cytosol))*(( 1.0 * R3) + ( 1.0 * R11) + ( 1.0 * R12))
	$Act_C_Cyt=(1/(cytosol))*(( 1.0 * R4) + ( 1.0 * R9) + ( 1.0 * R11) + (-1.0 * R12) + ( 1.0 * R12) + ( 1.0 * R13))
	$NFAT_Pi_Cyt=(1/(cytosol))*(( 1.0 * R9) + (-1.0 * R10) + (-1.0 * R12))
	$NFAT_Act_C_Cyt=(1/(cytosol))*(( 1.0 * R7) + (-1.0 * R8) + (-1.0 * R11))
	$NFAT_Pi_Act_C_Cyt=(1/(cytosol))*(( 1.0 * R8) + (-1.0 * R9) + (-1.0 * R17))
	$Inact_C_Cyt=(1/(cytosol))*((-1.0 * R13) + (-1.0 * R15))
 End Equations

End Model
!Parameter Count:24
!Variable Count:15
!Intermediate Count:17
!Equation Count:15

!Create a default data (CSV) file---remove this section if a separate .csv is used
File *.csv
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End File

File *.plt
 New Trend
 nfat_act_c_nuc
 nfat_pi_cyt
 nfat_act_c_cyt
 nfat_pi_act_c_cyt
End File

File overrides.dbs
 nlc.hist.hor=200
End File

Terms and Conditions